LIST OF PUBLICATIONS IN 1988-1996


ARTICLES:

  1. Martynov I.V., Bachurin S.O., Brel V.K., Dubova L.G., Dodonov M.V., Beznosko B.K. Synthesis and antimonoamine oxidase activity of fluoronitrocarboxylic acid hydrazides. // Chim. Pharm. J. 1988. V.22, N.11, P.1339-1343 (russ).
  2. Bachurin S.O., Sablin S.O., Grishina G.V., Gaydarova E.L., Dubova L.G., Zubova N.D. Monoamine oxidase catalysis of bioconversion of physiologically active 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridines. // Bioorganicheskaya chimiya. 1989. V.15, N.5, P.620-626 (russ).
  3. Beznosko B.K., Bachurin S.O., Brel V.K., Dodonov M.V., Dubova L.G., Zhuravleva L.V., Malygin V.V., Martynov I.V. The hypotensive action and antimonoamine oxidase activity of difluorocarboxilic acid hydrazides. // Dokl. AN SSSR. 1989. V.304, N.2, P.461-464 (russ).
  4. Bachurin S.O., Solyakov L.S., Lermontova N.N., Tkachenko S.E., Kalashnikov V.V., Serkova T.P., Petrova L.N. The role of dophamine-uptake system in the development of experimental parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its pyridine analogs. // Dokl. AN SSSR. 1989. V.307, N.3, P. 740-743 (russ).
  5. Lermontova N.N., Solyakov L.S., Bachurin S.O., Tkachenko S.E., Serkova T.P., Petrova L.N., Kalashnikov V.V.- An estimation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and some pyridine derivate's capability to produce parkinsonism. // Bull.Exp. Biol. Med. 1989. V.107, N.6, P. 699-701 (russ).
  6. Solyakov L.S., Petrova L.N., Kalashnikov V.V., Tkachenko S.E., Bachurin S.O. Effect of neuroactive derivatives of 4-phenylpyridine and 4,4'-bipyridine upon dophamine uptake by mice synaptosomes. // Neurochimia. 1989. V.8, N.3, P.395-399 (russ).
  7. Sablin S.O., Bachurin S.O.,Tkachenko S.E. Stylbasole Analogues of MPTP as Monoamine Oxidase (MAO) Substrates. // J.Neural Transmission. 1990. Suppl.32, P.119-122.
  8. Lermontova N.N., Solyakov L.S., Bachurin S.O., Serkova T.P., Petrova L.N., Draniy O.A., Tkachenko S.E., Kalashnikov V.V. Clinical and biochemical parameters of Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its methylphenyl- and methoxyphenyl-derivatives in the mouse C57BL/6. // Bull.Exp. Biol. Med. 1990. V.110, N.10, P.397-399 (russ).
  9. Sablin S.O., Tkachenko S.E., Bachurin S.O. Structure-activity studies of MAO-catalyzed dehydrogenation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) analogues. // Dokl. AN SSSR. 1991. V.318, N.1, P.228-331 (russ).
  10. Bachurin S.O., Dunayevetsky A.A., Lyubimov V.S., Martynov I.V. Kinetic features of the action of biologycally active compounds. 1. Irreversible metabolic inhibition of enzymes. // Chim. Pharm. J. 1991. V.25, N. 8, P.15-18 (russ).
  11. Bachurin S.O.,Lermontova N.N.,Tkachenko S.E. Pyridine Derivatives: Structure-Activity Relationships Causing Parkinsonism-Like Symptoms. // Rev.Environ.Toxicol. 1991. V.122, P.1-36.
  12. Ragulin V.V., Grigoryev V.V., Nemanova V.A., Tsvetkov Ye.N. Phosphorus-contaiming aminocarboxilic acids with an o-xylylene fragment. III. // Chim.-Pharm. J. 1991. V.25, N.3, P.50-52. Moskow."Medicina" (russ).
  13. Bachurin S.O., Sablin S.O., Lermontova N.N., Solyakov L.S., Dubova L.N., Tkachenko S.E. Molecular Basis of Discrepancies in Neurotoxic Properties Among 1-Methyl-4-Aryl-1,2,3,6-Tetrahydropyridines. // Molecular and Chemical Neuropathology 1992. V.17, N.3, P.189-200.
  14. Grigor'ev V.V., Nemanova V.A., Ragulin V.V. Specific differencies in action of competitive antagonists of NMDA receptors in hippocampal neurons of mices and rats. // Dokl. Ross. Akad. Nauk. 1992. V.326, N.4, P.742-745 (russ).
  15. Solyakov L.S., Petrova L.N., Drany O.A., Bachurin S.O. Modulatory action of kainic acid on the release of enogenous and exogenous glutamine from rat brain cortical synaptosomes. // Biol. Membrani. 1992. V.9, N.4, P.359-366 (russ).
  16. Bachurin S.O., Lermontova N.N., Sablin S.O., Solyakov L.S., Tkachenko S.E. Biochemical basis of structural electivity of MPTP-like neurotoxicity. // Ann. New York Acad. Sci. 1992. V.648, P.248-250.
  17. Lombardy V., Liptaj T., Beloeil J.-C., Snozzafava A., Dobrota D., Zalibera L., Marzuo F., Togner I., Bachurin S.O. Metabolite Mapping and Regional Differences of the Rabbit Spinal Cord. // J.Neurol.Orth. Med.Surg. 1992. V.13, P.1-15.
  18. Solyakov L.S., Drany O.A., Petrova L.N., Bachurin S.O. Modulatory action of kainic acid on glutamate release from rat brain cortical synaptosomes. // Ann. New York Acad. Sci. 1992. V.648, P.251-253.
  19. Bachurin S.O., Dunayevetsky A.A., Lermontova N.N., Serkova T.P. -Kinetic features of affects of biologically active compounds. II. The impact of the mechanism of inhibition on the efficacy of reversible enzymatic inhibition. // Chim. Phar. J. 1993. V.27, N11, P.1-8 (russ).
  20. Bachurin S.O., Lermontova N.N., Serkova T.P. Dithiocarbamates enhance neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its analogs. // Dokl. Ross. Acad. Nauk. 1993. V.328, N.3, P.399-402 (russ).
  21. Grigor'ev V.V.- The action of NMDA and quinolinic acid on rat cortical neurons. // Dokl. Ross. Acad. Nauk. 1993. V.330, N5, P.646-648 (russ).
  22. Grigor'ev V.V. The common receptors for aspartate and quinolinic acid, differ from NMDA-receptors in some rat brain cortical neurons. // Neurophysiology. 1993. V.1, N4, P.264-268.Kiev (russ).
  23. Grishina G.V., Bachurin S.O., Tkachenko S.E., Zefirov N.S. Modern chemistry of piperideines-3 (review). // Chemistry of Heterocyclic compounds. 1993. N.7, P.913-936 (russ). Riga, Latvia.
  24. Ramsay R.R., Sablin S.O., Bachurin S.O., Singer T.P. Oxdation of Tetrahydrostilbazole by Monoamine Oxidase A Demonstrates the Effect of Alternate Pathways in the Kinetic Mechanism. // Biochemistry. 1993. V.32, N.35, P. 9025-9030.
  25. Sablin S.O., Krueger M.J., Bachurin S.O., Solyakov L.S., Efange S.M.N., Singer T.P. Oxidation Products Arising from the Action of Monoamine Oxidase B on 1-Methyl-4-Benzyl-1,2,3,6-Tetrahydropyridine, a Nonneurotoxic Analogue of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine. // Journal of Neurochemistry. 1994. V.62, N.5. P.2012-2016. Raven Press, New York, USA.
  26. Sablin S.O., Krueger M.J.,Singer T.P.,Bachurin S.O., Khare A.B., Efange S.M.N., Tkachenko S.E. Interaction of Tetrahydrostilbazoles with Monoamine Oxidase A and B. // Journal of Medicinal Chemistry. 1994. V.37, N.1, P.151-157. American Chemical Society, USA.
  27. Solyakov L.S., Petrova L.N., Bachurin S.O. Action of kainic acid on the release of D-[3H]aspartate from synaptosomes and rat brain cortical slices. // Biologicheskiye membrani. 1994. V.11, N4, P.381-387. Moscow."Nauka" (russ).
  28. Lermontova N.,Drany O., Dobrota D., Mezeshova V., Lombardi V., Bachurin S. Relative resistance of Rabbits to MPTP Neurotoxicity. // Mol. Chem. Neuropathology. 1995. V.25, N2-3, P.135-141. Humana Press, USA.
  29. Solyakov L.S., Drany O.A., Dobrota D., Mezeshova V., Bachurin S.O., An incresed release of L-[14C]glutamate from partial ischemia-exposed rabbit brain cortical slices. // Biologicheskiye membrani. 1995. V.12, N.4, P.351-359. Moscow. "Nauka" (russ).
  30. Solyakov L.S., Drany O.A., Dobrota D., Mezeshova V., Machac S., Vachova M., Bachurin S.O., Action of stobadin on glutamatergic system in rat brain after local ischemia. // Biologicheskiye membrani. 1995. V.12, N5, P.489-495. Moscow."Nauka" (russ).
  31. Solyakov L.S., Dobrota D., Drany O.A. Vachova M., Mezeshova V., Machac S., Bachurin S.O., Lombardy V. Transport mechanism of L-[14C]-glutamate in cortical slices and synaptosomes of rabbits exposed to brain ishemia and reperfusion. // Mol. Chem. Neuropathology. 1995. V.25, N2-3, P.123-134.
  32. Solyakov L.S., Petrova L.N., Bachurin S.O. Action of Kainic Acid on the Release of D-[3H]Aspartate from Synaptosomes and Rat Brain Cortical Slices. // Membrane and Cell Biology. 1995. V.8, P.391-398. Harwood Acad.Publ.GmbH.
  33. Bachurin S.O., Lukoyanov N.V., Petrova L.N., Solyakov L.S., Tkachenko S.E., Raevsky O.A., Inhibition of dopamine uptake system by analogs of neurotoxic metabolite MPP (1-Methyl-4-Phenylpyridinium). Structure-activity relationships. // Dokl. Ross. Akad. Nauk. 1996. V.346, P. 549-551. Moscow. Nauka. (russ.)
  34. Bachurin S., Shevtsova E., Lermontova N.,Serkova T., Ramsay R.R. The effect of dithiocarbamates on the neurotoxic action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and on mitochondrial respiratory chain. // NeuroToxicology. 1996. V.17(3-4), P.897-904
  35. Sablin S.O., Krueger M.J., Yankovskaya V.L.,Tkachenko S.E.,Razdolsky A.N.,Bachurin S.O.,Ramsay R.R.,Singer T.P. Inhibition of NADH Oxidation by 1-Methyl-4-phenylpyridinium Analogs as the Basis for the Prediction of the Inhibitory Potency of Novel Compounds. // J.Biochem. Toxicology. 1996. V.11, N1, P.33-43.
  36. Shumakovich G.P., Yaropolov A.I., Dubova L.G., Bachurin S.O. Bioelectronatalyse by Monoamine Oxidase on Electrodes Modified with Organic Acceptors of Electrons. // Dokl. Ross. Acad. Nauk. 1996. V.348, N5, P.637-640. (russ).
  37. Solyakov L.S., Drany O.A., Dobrota D., Mezeshova V., Machac S., Vachova M., Bachurin S.O., Action of Stobadin on the Glutamatergic System in Rat Brain After Local Ischemia. // Membr. And Cell Biol. 1996. V.9, N5, P.509-514. Amsterdam B.V. The Netherland, Harwood Academic Publishers, GmbH.
  38. Solyakov L.S., Drany O.A., Dobrota D., Mezeshova V., Bachurin S.O., An Incresed Release of L-[14C]Glutamate from Partial Ischemia-Exposed Rabbit Brain Cortical Slices. // Membr. And Cell Biol. 1996. V.9, N4, P.359-368. Amsterdam B.V. The Netherland, Harwood Academic Publishers, GmbH.
  39. Lermontova N., Lukoyanov N., Serkova T., Lukoyanova E., Bachurin S. Effect of Tacrine on Deficits in Acute Avoidance Performance Induced by AF64A in Rats. // Molec. Chem. Neuropathol. 1998, V.33, N1, P.51-61.
  40. Bachurin S.O., Dubova L.G., Shumakovich G.P., Yaropolov A.I. Monoamine oxidase catalysis on electrodes modified with artificial acceptors of electrons. // Bioelectrochemistry and Bioenergetics, 1998, V.46. P.185-191.
  41. S.O. Bachurin, V.I. Fetisov, A.Z. Afanasiev, C.V. Afanasieva, L.G. Dubova, V.L. Yankovskaya, T.V. Mukhina. Substituted 2- and 4-[2-[3-indolyl]ethynyl]pyridinium salts - as MAO-B inhibitors. Quantitative structure-activity modeling. // Doklady Russ.Acad.Sci. 1999, V.364, N.6. P.782-785.
  42. Miagkova M.A., Bachurin S.O., Savitskii A.A., Stanislav M.L., Balabanova R.M., Zhokova N.I., Panchenko O.N., Savitskaia Iu.A. Immunoenzyme assay for detection of natural antibodies against vasopressin in systemic lupus erythematosus. // Klin.Lab.Diag. 1999, V.4, P.20-24.
  43. V.I. Fetisov, A.V. Kotov, P.B., S.O.Bachurin, L.N. Petrova, O.A. V.A. Kolesova, A.L. Chimishkjan, T.V.Mukhina, I.V.Martynov. Synthesis of 4-phosphorilated derivatives of allofanic acid and their action on glutamate-induced 45Ca2+-uptake by rat brain synaptosomes. // Doklady Russ.Acad.Sci. 1999, v.336, ¹6: 774-776
  44. S.O. Bachurin. Search for agents for neurodegenerative disorders treatment. From Science to Industry. 1999, 8: 17-24 (russ).
  45. Miagkova M.A., Savitskii A.A., Bachurin S.O., Panchenko O.N., Savitskaia Iu.A., Zhokova N.I. Immunochemical properties of antibodies to dermorphine and its analogs in patients with neurodegenerative disorders. // Immunology 1999, V.4, P.52-55 (russ).
  46. V.I. Fetisov, A.V. Kotov, P.B. Gordeev, S.O.Bachurin, L.N. Petrova, O.A. Lukjanov, O.A. Raevsky, I.V.Martynov. Synthesis of 3-hydroxy-1,2-dihydroquinoline-4-ons and their action on glutamate-induced 45Ca2+-uptake by rat brain synaptosomes. // Doklady Russ.Acad.Sci. 1999, v.367, No.6, P.776-779.
  47. V.V. Grigoriev, V.V. Kalashnikov,, I.P. Kalashnikova, V.A. Nemanova, S.E. Tkachenko, S.O. Bachurin. Synthesis and anticonvulsive activity of N-naphtyl-(4-pyridinyl)methylamines and their analogs. // Khim. Pharm. Journal, 1999, N8, P.3-5.
  48. S. Bachurin, G. Oxenkrug, N. Lermontova, A. Afanasiev, B. Beznosko, G. Vankin, E. Shevtzova, T. Mukhina, T.Serkova. N-acetylserotonin, melatonin and their derivatives improve cognition and protect against p-amyloid neurotoxicity. // Ann. New York Acad.Sci., 1999 v.890, P.155-166.
  49. Lermontova N.N., P'chev V.K., Beznosko B.K., Van'kin G.I., Koroleva I.V., Lukoyanova E.A., Mukhina T.V., Serkova T.P., Bachurin S.O. Effects of 17beta-Estradiol and Its Isomer 17alpha-Estradiol on Learning in Rats with Chronic Cholinergic Deficiency in the Brain. Bull Exp Biol Med. 2000 May 1;129(5):525-527.
  50. Lermontova N.N., Lukoyanov N.V., Serkova T.P., Lukoyanova E.A., Bachurin S.O. Dimebon Improves Learning in Animals with Experimental Alzheimer's Disease. Bull Exp Biol Med. 2000 Jun 1;129(6):640-642.
  51. Ì.À. Myagkova, S.I. Gavrilova, N.N. Lermontova, Y.B. Kalyn, N.D. Selezneva, G.A. Garikov, I.V. Kolykhalov, T.V. Abramenko, T.P. Serkova, S.O. Bachurin. The relationships between beta-amyloid and neurotransmitters in blood of patients with Alzheimer's disease and with senile dementia of Alzheimer's type. Bull.Exp.Biol.Med., 2001, v.131, No2, P:156-159 (russ)
  52. Oxenkrug G., Requintina P., Bachurin S. Antioxidant and Anti-Aging Activity of N-Acetylserotonin and Melatonin in the in vivo models. // Ann.N.Y Acad. Sci., 2001, v.939, P.190-199.
  53. Bachurin S., Tkachenko S., Baskin I., Lermontova N., Mukhina T., Petrova L., Ustinov A., Proshin A., Grigoriev V., Lukoyanov N., Palyulin V., Zefirov N. Neuroprotective and cognition enhancing properties of MK-801 flexible analogs. Structure-activity relationships. // Ann.N.Y Acad. Sci. 2001, v.939, P.219-236.
  54. Bachurin, S., Bukatina, E., Lermontova, N., Tkachenko, S., Afanasiev, A., Grigoriev, V., Grigorieva, I., Ivanov, Yu., Sablin, S., Zefirov, N. Antihistamine agent Dimebon as novel neuroprotector and cognition enhancer. // Ann.N.Y Acad. Sci. 2001, v.939, P.425-435.
  55. Bachurin S.O. Medicinal-chemistry approaches for directed search of agents for Alzheimer's disease treatment and prevention. // Voprosy Med.Chem., 2001, v.47, ¹2, P:155-197 (russ).
  56. Bachurin S.O., Byzova N.A., Dubova L.G., Yaropolov A.I. Catalysis of monoamine oxidase of amine oxidation by organic acceptors of electrons. Dokl. Russ. Acad. Sci., 2001, v.376, ¹2, P:200-203.
  57. Ivanov Yu. Ya., Afanasiev A.Z., Bachurin S.O. Calcium-antagonistic activity of some hydrogenated dericatives of pyrido[3,4-b]indoles. Khim. Pharm. Journal, 2001, v.35, ¹ 7, P:7-8.
  58. Shumacovich G.P., Bachurin S.O., Dubova L.G., Zaytceva E.A., Yaropolov A.I. Monoamine oxidase bioelectrocatalysis on glass-carbon electrode with azine stains as effective artificial electron acceptors. Dokl. Russ. Acad. Sci. 2001, ò.377, ¹6, Ñ.778-782
  59. Mukhina T.V., Bachurin S.O., Lermontova N.N., Zefirov N.S. Versatile Computerized System for Tracking and Analysis of Water Maze Tests. Behav Res.Methods. Instrum. Comput. 2001, v.33, ¹3, Ð:371-80.
  60. Baskin I.I., Halberstam N.M., Mukhina T.V., Palyulin V.A., Zefirov N.S. The Learned Symmetry Concept in Revealing Quantitative Structure-Activity Relationships with Artificial Neural Networks. Sar & QSAR in Environmental Research, 2001, v.12, P:410-416.
  61. Lermontova NN, Redkozubov AE, Shevtsova EF, Serkova TP, Kireeva EG, Bachurin SO. Dimebon and Tacrine Inhibit Neurotoxic Action of beta-Amyloid in Culture and Block L-type Ca(2+) Channels. Bull Exp Biol Med. 2001 Nov;132(5):1079-83.
  62. Shevtzova E.F., Kireeva E.G., Bachurin S.O. The effect of fragment of (-amyloid peptide 25-35 on nonselective permeability of mitochondria. Bull Exp Biol Med. 2001 Dec;132(12):652-656.
  63. Tikhonova IG, Baskin II, Palyulin VA, Zefirov NS, Bachurin SO. Structural Basis for Understanding Structure-Activity Relationships for the Glutamate Binding Site of the NMDA Receptor. J Med Chem. 2002 Aug 29;45(18):3836-3843.
  64. Ivanov Yu. Ya., Tkachenko S.E., Proshin A.N., Ustinov A.K., Bachurin S.O. m-Cholinergic properties of 2-amino-2-thiazoline derivatives. Khim.Parm.Journal., 2002, v.36, ¹11, ð:8-9 (russ).
  65. Matveeva E.D., Podrugna T.A., Morozkina N.Yu., Zefirova O.N., Alexeev A.S., Bachurin S.O., Pellicciari R., Zefirov N.S. Synthesis of compounds which interact with glutamate receptors. I. New applied synthesis of aminoindanedicarbonic acid (AIDA). Journal Org. Khimii (rus), 2002, v.38, N.12:1825-1829.
  66. Matveeva E.D., Podrugina T.A., Morozkina N.Yu., Zefirova O.N., Seregin I.V., Bachurin S.O., Pellicciari R., Zefirov N.S. Synthesis of compounds which interact with glutamate receptors. II. Synthesis of spirogindantoines in series of indane derivatives. Journal Org. Khimii (rus) 2002, v.38, N.12:18230-1835.
  67. Bachurin S.O. Medicinal chemistry approaches for treatment and prevention of Alzheimer's disease. Medicinal Research Reviews, 2003, 23(1):48-88.
  68. Lermontova N.N., Mukhina T.V., Vankin G.I., Serkova TP, Bachurin SO. Comparison of the Effect of NT-0409 and Antidementia Drugs on Learning and Memory in Rats with Chronic Cerebral Cholinergic Deficiency. Bull Exp Biol Med., 2003, v.135, ¹1: 58-61.
  69. Ivanov Yu. Ya., Tkachenko S.E., Proshin A.N., S.O. Bachurin. 2-Amino-2-Thiazoline derivatives - new chemotype with muscarine-like activity. Biomed.Khim., 2003, v.49, N1:92-95.
  70. Bachurin S.O., Shevtsova E.P., Kireeva E.G., Oxenkrug G.F., Sablin S.O. Mitochondria as a target for neurotoxins and neuroprotective agents. // Ann.N.Y Acad. Sci., 2003, v. 993: 334-344.
  71. Mukhina T.V., Lermontova N.N., Van'kin G.I., Oettel M., P'chev V.K., Bachurin S.O. Effects of estrogens on learning of rats with chronic brain cholinergic deficit in Morris water maze. Zh Vyssh Nerv Deiat Im I P Pavlova. 2003; 53(2):208-214.
  72. Bondarenko N.A., Lermontova N.N., Bondarenko G.N., Gulyukina N.S. Dolgina T.M., Bachurin S.O., Belezkaya I.P. Biological Activity of 1-Arylethylphosphonic Acids. Khim-Pharm. Journal, 2003, 37, 5:7-9.

    Books (chapter in a book):

  73. Bachurin S.O. Medicinal chemistry of focused search of agents for treatment and prevention of neurodegenerative diseases on example of Alzheimer's disease. In the book: Neurodegenerative diseases and ageing. Eds. I.A. Zavalishin, N.N. Yakhno, S.I. Gavrilova. Moscow, "ELF IPR press", 2001; P.399-454.

ABSTRACTS:

  1. Bachurin S.O., Beznosko B.K., Brel V.K., Kemenov V.A., Martynov I.V. Enzymes as biological target of action of physiological active substancies. Monoamine oxidase inhibition and hypotensive characteristic of difluorocarboxilic acid hydrazides. // Abstr. V All-Union Symposium on Enzyme Engineering. -1985. P.136 (russ).
  2. Bachurin S.O., Tkachenko S.E., Kalashnikov V.V., Lermontova N.N., Solyakov L.S., Sablin S.O. Comparative study of pyridinium herbicides neurotoxicity mechanisms. // Pestycydy.-1988. N.3. P.55.
  3. Bachurin S.O., Lermontova N.N., Solyakov L.S., Sablin S.O., Tkachenko S.E. Different neurochemical mode of action of pyridinium herbicides. // Neurochemistry International -1988. V. 13, Suppl.1, P.85.
  4. Bachurin S.O., Dunayevetsky A.A., Lyubimov V.S. Kinetic mechanisms of inhibition of enzymes by biologycally active metabolites. // Engineering Enzymology //. Abstr. VI All-Union Symposium on Enzyme Engineering. -1988. P.10, (russ).
  5. Bachurin S.O., Sablin S.O., Dubova L.N. Kinetic Properties of Monoamine Oxidase in Dehydrogenisation Reaction of Physiological Active Aryltetrahydropyridines. // In: Engineering Enzymology. Abstr. VI All-Union Symposium on Enzyme Engineering. -1988. P.11-12 (russ).
  6. Tkachenko S.E., Kalashnikov V.V., Mashkova I.V., Bachurin S.O. Regioselective synthesis of 2- and 4-aryl-(hetaryl)pyridines. // Chemistry and Technology of Pyridine Containing Pesticides. Abstr. All-Union Confer. Chernogolovka. -1988. P.131-132 (russ).
  7. Bachurin S.O., Solyakov L.S., Tkachenko S.E., Lermontova N.N., Petrova L.N., Serkova T.P. Biochemical criteria of parkinsonism development by action of MPTP and its pyridine analoges as a method of selection of nontoxic pesticides in series pyridine containing compounds. // Chemistry and Technology of Pyridine Containing Pesticides. Abstr. All-Union Confer. Chernogolovka. -1988. P.240-241 (russ).
  8. Bachurin S.O., Grigoriev V.V., Nemanova V.A. Specific and functional differences of NMDA and kainate receptors. // Neurochemistry Intern. -1988. V.13. Suppl.1. P.119.
  9. Beznosko B.K., Bachurin S.O., Brel V.K., Dodonov M.V., Dubova L.G., Zhuravleva L.V., Malygin V.V. Relative estimation of the hypotensive and antimonoamine oxidase action of difluorocarboxilic acid hydrazides. // Synthesis, pharmacology and clinical aspects of novel psychotropic and cordiovascular compounds. Abstr. of Interrepubican scientific and practical conference. Volgograd. -1989. P.12 (russ).
  10. Bachurin S.O., Grigoriev V.V., Tatarinov A.S., Dubova L.G., Nemanova V.A. Rapkin A.I. Neurotropic property of amido-polyhalogencarboxilic acid. // Chemie of physiology active compounds. Abstr. All-Union Symposium. Chernogolovka. -1989. P.32 (russ).
  11. Tkachenko S.E., Kalashnikov V.V., Kalashnikova I.V., Muchin S.V., Lermontova N.N., Solyakov L.S., Sablin S.O., Bachurin S.O. Directed synthesis of physiologically active 4-aryl- and 4-styrylpyridines and its hydrogenated products. // Chemie of physiology active compounds. Abstr. All-Union Symposium. Chernogolovka. -1989. P.229 (russ).
  12. Bachurin S.O., Lermontova N.N., Sablin S.O., Solyakov L.S. Molecular basis of selective neurotropic activity of bioactive 4-aryltetrahydropyridine derivatives. // Molecular Basis of Actiion Of Bioactive Substances on Behaviour. Abstr.Inter.Symp.Tallin. -1989. P.8.
  13. Bachurin S.O., Lermontova N.N., Solyakov L.S., Petrova L.N., Serkova T.P., Tkachenko S.E. Estimation of neurotoxicity of pyridine-containing pesticides as a possible ectoxicological factor. // Abstr.Int.Symp. "Environmental Stress" -1989. P.47.
  14. Bachurin S.O., Sablin S.O., Dubova L.G. Monoamine oxidase (MAO) catalysis of bioconversion of 1-methyl-4-aryl-1,2,3,6-tetrahydropyridines to physiologically active metabolites. // Bioelectrocatalysis. -1990. v.4. P.63.
  15. Bachurin S.O., Lermontova N.N., Solyakov L.S., Sablin S.O. Molecular basis of discrepancies in neurotoxic properties among 1-methyl-4-aryl-1,2,3,6-tetrahydropyridines (MATR).// Abstracts of Eur. Soc. Neurochem. 8th General Meeting. -1990. July 23-28. Leipzig. P. 137.
  16. Chistyakova L.M., Sapegin A.M., Bachurin S.O., Raevsky O.A., Zefirov N.S. Expertic system for central nervous system metabolism prognosis. // Abstr. II All-Union Confer. "Artificial intellect-90". -1990. P.118-121
  17. Bachurin S.O., Lermontova N.N., Sablin S.O., Solyakov L.S., Tkachenko S.E. Biochemical basis of molecular selectivity of MPTP-like neurotoxins. // Abstr. 3rd Int. Symp. Neurotoxins in Neurobiology. Piriapolis Uruguay. -1991. P.1.
  18. Bachurin S.O., Sablin S.O. & Dubova L.G. Enzymatic Basis of Neurodegenerative Discrepancies in Number of MPTP Analogues. // Abstr. 5th Int. Sym. New Frontierrs in Biochem. and Biophysics in Neurol. Disorders. Bristol. - 1991. P.37.
  19. Pshezhetzky A.V., Ladigin A.E., Vorob'eva I.A., Shvyadas V.K., Bachurin S.O., Pshezhetzky V.S. Potentiometric biosensor for biogenic amines measurements. // In: Engineering Enzymology. Abstr. VII All-Union Symposium. -1988. P.10 Moscow. 1991. P.114-115 (russ).
  20. Bachurin S.O., Lermontova N.N., Ramsay R.R., Serkova T.P., Shevtzova E.F., Singer T.P. Dithiocarbamates Potentiate Dopaminergic Neurotoxicity of MPTP and its Analogues. Structure-Activity Relationships. //Abst. 4th Int. Neurotoxicology Assotiation Meeting. Denmark. -1993. P. 8.
  21. Lermontova N., Drany O., Dobrota D., Mezesova V., Bachurin S. Rabbits`model of MPTP-related Parkinsonism. // IVth Intrnational Symposium on Neurotoxins in Neurobiology. Bath,UK. -1993, P.47.
  22. Solyakov L.S., Petrova L.N., Bachurin S.O. Action of Kainic Acid on D-[3H]aspartate Release from Rat Cortical Synaptosomes and Microslices. // IVth Intrnational Symposium on Neurotoxins in Neurobiology. Bath,UK -1993. P.39.
  23. Bachurin S., Lukoyanov N., Petrova L., Solyakov L., Tkachenko S., Raevsky O. Structure-activity relationshios of a series of novel inhibitors of dopamine uptake system. // XIIIth International Symposium on Medicinal Chemistry. Paris. -1994. P.22.
  24. Tkachenko S.E., Serova T.M., Palyulin V.A., Proshin A.N., Averina N.V., Petrova L.N., Solyakov L.S., Bachurin S.O., Zefirov N.S. Structure-aktivity Relationships of a Series of Polycyclic and Bridged Compounds Affecting on Ca2+ Homeostasis. // XIIIth International Symposium on Medicinal Chemistry. Paris. -1994. P.75.
  25. Bachurin S.O., Sablin S.O., Razdolsky A.N., Tkachenko S.E., Singer T.P. Structure-metabolism Relationships of Monoamine Oxidase Catalysis of Biotransformation of Tetrahydropyridine Derivatives. // Third IUBMB Conference "Molecular Recognition". Singapore. -1995. P.138.
  26. Bachurin S., Lermontova N., Shevtsova E., Petrova L., Solyakov L., Serkova T., Singer T., Ramsay R. Mechanism of dithiocarbamates potentiation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity. // NeuroToxicology. -1995. V.16, N 3, P.547.
  27. Bachurin S.O., Lukoyanov N.V., Tkachenko S.E., Raevsky O.A., Zefirov N.S. Search for Novel Neuroprotectors in Series of Polycyclic and Bridged Compounds Affecting on Ca2+ Homeostasis in Brain. Structure-Activity Study. // XIVth International Symposium on Medicinal Chemistry. Maastricht, the Netherlands. -1996. P. 6.37.
  28. Drany O.A., Bachurin S.O. Influence of the 25-35 fragment of ( -amiloid peptide on calcium homeostasis in nervous cells. // 8-th Intern. Congress of the Czech and Slovak Neurochemical Society. Martin, Slovakia. -1996. P.45.
  29. Lermontova N.N., Lukoyanov N.V., Serkova T.P., Lukoyanova E.A., Bachurin S.O. The application of active test on the AF64A-treated rats to study the medicines for alzheimer's diseas treatment. // 8-th Intern. Congress of the Czech and Slovak Neurochemical Society. Martin, Slovakia. -1996. P.109.
  30. Zefirov N.S., Bachurin S.O., Khamin A.S., Kiseleva E.G., Klochkov S.G., Palyulin V.A., Tkachenko S.E. Structure-activity Relationships and Computer-aided Design of Oncolytic Drugs. //11th European Sympos. on Quantitative Structure-Activity Relationships: Computer-Assisted Lead Finding and Optimisation. Lausanne, Shvetherland. -1996. P-32.A.
  31. Bachurin S., Lukoyanov N., Petrova L., Solyakov L., Tkachenko S., Raevsky O. Dopamine uptake inhibitors in series of stylbazoles derivatives. Structure-activity relationships. // J.Neural Transmission. -1996, v.103, N10, P.XVIII.
  32. Lermontova N.N., Lukoyanov N.V., Serkova T.P., Lukoyanova E.A. and Bachurin S.O. The applicaton of activa avoidance test on the AF64A-treated rats for primary selection of medicines for Alzheimer's disease treatment. // J.Neural Transmission. -1996, v.103, N10, P.XXXIX
  33. Bachurin S., Grigoriev V., Kalashnikov V., Nemanova V. and Tkachenko S. Novel potential drugs with a broad spectrum of anticonvulsive activity. // Eur. J. Neurol., -1996, v.3, suppl.5, P.137.
  34. Bachurin S.O., Afanasiev A.Z., Grigoriev V.V., Lermontova N.N., Lukoyanov N.V., Tkachenko S.E., Zefirov N.S. Directed selection of novel neuroprotectors for Alzheimer's disease treatment. J. Neurochemistry, 1997, v. 69, Suppl.: S48B.
  35. Lukoyanov N.V., Maslov A.A., Bocharnikova E.A., Lermontova N.N., Bachurin S.O. Effect of cholinotoxin AF64A on the GABA-induced chloride influx in hippocampus. J. Neurochemistry, 1997, v.69, Suppl.: S184B.
  36. S.O. Bachurin, L.N. Petrova The effect of dithiocarbamates on dopamine transport systems. Abst. 6th Meeting of the International Neurotoxicological Association, Szeged, Hungary, 1997, P.92.
  37. N.Lermontova, E.Shevtzova, T.Serkova, E.Kireeva and S.Bachurin. Tacrine protects cultured cerebellar granule neurons against (-amyloid-induced neurotoxicity Abst. 4th Congr. Eur. Soc. Clinical Neuropharmacology, Dec.1-4, 1997, Eilat, Israel. P1.
  38. Bukatina E.E., Afanas'ev A.Z., Bachurin S.O., Grigor'ev V.V., Grigorieva l.V., Tkachenko S.E., Yurovskaya M.A., Zefirov N.S. Medicine for treatment of Alzheimer's disease. Abst. 4th Congr. Eur. Soc. Clinical Neuropharmacology, Dec.1-4, 1997, Eilat, Israel. P2.
  39. S.O. Bachurin, E.E. Bukatina, V.V. Grigoriev, I.V. Grigorieva, Yu.J. Ivanov, N.V. Lukoyanov, S.E. Tkachenko, N.S. Zefirov Cognition enhancing properties of antihistamine drug Dimebon // Neurobiol. Aging, 1998, Suppl.4S, No. 754.
  40. S. Bachurin, N. Lermontova, E. Shevtzova, T. Serkova, E. Kireeva. Prevention of (-amyloid-induced neurotoxicity by tacrine and dimebon. J. Neurochemistry, 1998, v. 71, Suppl.1: S68A.
  41. Grigoriev V.V., Drany O.A., Proshin A.N., Tkachenko S.E., Bachurin S.O. Isothiuronium derivative potentiate kainate-induced current in purkinje neurons of rat cerebellum. Abstr. 9th Int. Congress Czech and Slovak Neurochem., Soc., Martin, Slovakia, September 6-10, 1998. P.46.
  42. S. Bachurin, N. Lermontova, E. Shevtsova, T. Serkova, E. Kireeva, G.Oxenkrug. (-Amyloid-induced neurotoxicity is prevented by N-acetyl-serotonin, the precusor of melatonin. 9th Int. Congress Czech and Slovak Neurochem., Soc., Martin, Slovakia, September 6-10, 1998. P.94.
  43. E. Shevtsova, S. Bachurin, E. Kireeva. The influence of (-amyloid peptide (25-35) on mitochondrial permability transition. 9th Int. Congress Czech and Slovak Neurochem., Soc., Martin, Slovakia, September 6-10, 1998. P.103.
  44. Bachurin S.O., Grigoriev V.V., Drany O.A., Proshin A. N., Tkachenko S.E. Isothiouronium derivative potentiates Ampa/kainate - induced currents in rat cerebellar Purkinje neurons. // J.Neurochem.1999, v.73, Suppl., S143D.
  45. S.Bachurin, N. Lermontova, E. Shevtzova, T. Serkova, E. Kireeva. Comparative study of tacrine and dimebon action on mitochondrial permability transition and (-amyloid-induced neurotoxicity. // J.Neurochem.1999, v.73, Suppl., S185D.
  46. G. Oxenkrug, S. Bachurin, I. Prakhie, P. Requintina, A. Afanasiev, B. Beznosko, G. Vankin, N. Lermontova, T. Serkova. Neurobiological effects of the new indolalkylamine derivative. // Biol. Psychiatry, 1999, V. 45, N.85:92S.
  47. S.O. Bachurin. Medico-biochemical approaches on directed search for medicines for prevention from and treatment of Alzheimer's Disease. Proc.2nd Russian Conf., "Alzheimer's Disease and Ageing: from Neurobiology to Therapy". Oct.18-20, 1999, P. 20-23.
  48. S.O. Bachurin, N.N. Lermontova, N.V. Lukoyaov, T.P. Serkova, E.F. Shevtzova, E.G. Kireeva. Dimebon improves learning in animal model of dementia and protects cultural neurons against degeneration, induced by (-amyloid. Proc.2nd Russian Conf., "Alzheimer's Disease and Ageing: from Neurobiology to Therapy". Oct.18-20, 1999, P. 110.
  49. V.V. Grigoriev, O.A. Drany, S.O. Bachurin. Potentiation of AMPA/Kainic acid' receptors as possible mechanism of cognition functions and memory improvements in laboratory animal model with chronic partial deprivation of cholinergic system. Proc.2nd Russian Conf., "Alzheimer's Disease and Ageing: from Neurobiology to Therapy". Oct.18-20, 1999, P. 141-142.
  50. S.E. Tkachenko, A.N. Proshin, A.N. Pushin, L.N. Petrova, S.O. Bachurin, N.S. Zefirov. Regiocontrol in dehydrohalogenisation of isomeric cyclic derivatives of (-halogenisothiourea and physiological activity of reaction products. Abstr. XX All-Rusian Conf. Chemistry and Technology of Organic Compounds of Sulfur. Kazan, 18-23 Oct., 1999, P. C23.
  51. Bachurin S, Lermontova N., Afanasiev A., Beznosko B., Vankin G., Shevtzova E., Kireeva E., Serkova T. and Oxenkrug G. Neuroprotective and cognition enhancing properties of melatonin, N-acetylserotonin and their synthetic analogs in experimental models of Alzheimer's Disease type neurodegeneration. Restorative Neurobiology and Neurosci., 2000, v.16, N1, P.41.
  52. Tkachenko S ., Bachurin S., Proshin A., Ustinov A., Petrova L., Zefirov N. Synthesis and neurochemical properties of substituted tribenzylamines (open analogs of MK-801) as potent NMDA-receptor linked ion channel blockers. Restorative Neurobiology and Neurosci., 2000, v.16, N1, P.72-73.
  53. Shevtsova E., Kireeva E., Bachurin S. (-Amyloid peptide (25-35) as a trigger of mitochondrial permeability transition. Eur. J. Med. Res. 2000, v.5, Suppl.1., P.30-31.
  54. Lermontova N.N., Beznosko B.K., Vankin G.I., Ivanova T.A., Koroleva I.V., Mukhina T.V., Serkova T.P., Oettel M., Patchev V., Bachurin S.O. 17beta-Estradiol, 17alpha-Estradiol and the synthetic estrogen J861 enhance learning in rats with partial chronic impairment of cholinergic functions. Abst. Xth Magdeburg International Neurobiological Symposium: Mechanisms of Learning and Memory. Sept.16-19, 2000, Magdeburg.
  55. Markova E.G., Lermontova N.N., Mukhina T.V., Van'kin G.I., Bachurin S.O. AF64A leads to impairment of learning in morris water maze test and increases NADPH-diaphorase reactivity in neurons of NMB, fronto-parietal cortex and neostriatum in rats. Eur. J., Neurosci., 2000, v.12, Suppl.11, P.270.
  56. Bachurin, S., Bukatina, E., Lermontova, N., Tkachenko, S., Afanasiev, A., Grigoriev, V., Grigorieva, I., Ivanov, Yu., Sablin, S., Zefirov, N. Antihistamine agent Dimebon as novel neuroprotector and cognition enhancer. Abst. 5th Int. Conference on Neuroprotective Agents, Sept. 17-21, 2000, Lake Tahoe, Calofornia, USA.
  57. Bachurin S., Tkachenko S., Baskin I., Lermontova N., Petrova L., Ustinov A., Proshin A., Grigoriev V., Lukoyanov N., Palyulin V., Zefirov N. Neuroprotective and cognition enhancing properties of MK-801 flexible analogs. structure-activity relationships. Abst. 5th Int. Conference on Neuroprotective Agents, Sept. 17-21, 2000, Lake Tahoe, Calofornia, USA.
  58. Oxenkrug G., Requintina P., Afanasiev A., Bachurin S. Antioxidant and anti-aging activity of N-acetylserotonin, melatonin and their synthetic analogs in the in vivo models. Abst. 5th Int. Conference on Neuroprotective Agents, Sept. 17-21, 2000, Lake Tahoe, Calofornia, USA.
  59. Mukhina T.V., Lermontova N.N., Bachurin S.O. Automated system for tracking and behavioral analysis. Proceedings 3rd Int. Conf. "Methods and Techniques in Behavioral Research" - "Measuring Behavior - 2000", 15-18 August, 2000, Nijmegen, Netherlands, p.224-225.
  60. Mukhina, T.V.; Bachurin, S.O.; Tkachenko, S.E.; Baskin, I.I.; Palyulin, V.A.; Zefirov, N.S. Application of the Artificial Neural Networks Methodology for Studying Quantitative Structure-Activity Relationships in the Set of MK-801 Analogues. Proceedings of the VII All-Russia Conference "Neurocomputers and their Applications" NC-2001 with International Participance, Moscow, 2001, February 14-16 pp.425-427. [Full text in PDF]
  61. Mukhina, T.; Bachurin, S.; Tkachenko, S.; Petrova L.; Ustinov, A.; Proshin, A.; Baskin, I.; Artemenko, N.; Halberstam, N.; Palyulin, V.; Zefirov, N. Neural Network QSAR Study of Open-Chain Analogs of MK-801. ACS'2000. International School-Seminar on Computer Automation and Imformatization. Moscow. 2000 pp.49-50.
  62. Bachurin S.O., Kireeva E.G., Lermontova N.N., Shevtsova E.P. Mitochondria as the target of neurotoxins. J.Neurochem., 2001, v.77 Suppl.1, P:33.
  63. Bachurin S.O., Myagkova M.A., Gavrilova S.I., Kalyn Ya.B. and Lermontova N.N. The relationships between content of autoantibodies against (-amyloid peptides, neurotransmitters and neuropeptides in blood of patients with different types of Alzheimer's disease. J.Neurochem., 2001, v.77 Suppl.1, P:22-23.
  64. S.O. Bachurin "Focused design and study of novel neuroprotectors and cognition-enhancers in series of glutamate receptors ligands". Abstr. 10th Int. Symposium "The New Fronties of Neurochemistry and Biophysics on Diagnosis and Treatment of Neurological Diseases". Firenze, Italy, October 11-13, 2001, ð:24-25.
  65. Bachurin S.O. "Medicinal Chemistry Technologies for focused search of agents for neurodegenerative disorders treatment and prevention." Proc. IX Int. conf. "New technologies in medicine and ecology". Gurzuf, Ukraine, June 1-10, 2001, p: 334-335.
  66. I.Baskin, V.Palyulin, S. Bachurin, S.Tkachenko, N.Zefirov. "Computer Modeling of NMDA-Receptor Channel Site Interaction with MK-801 and its Analogs. Abstr. ISN - Rio Satellite Meeting "Cell Communication in the Nervous System - Function and Dysfunction". 22-24 Aug. 2001, Rio de Janeiro, Brazil. P2-27.
  67. Bachurin S.O., Myagkova M.A., Gavrilova S.I., Kalyn Ya.B. and Lermontova N.N. The relationships between content of autoantibodies against (-amyloid peptides, neurotransmitters and neuropeptides in blood of patients with different types of Alzheimer's disease. J.Neurochem., 2001, v.77 Suppl.1, P:22-23.
  68. Bachurin S., Zefirov N. Molecular modeling and synthetic design of efficient neuroprotectors. Abst. Scientific Conference "problems of Organic Chemistry. Sept. 17-21, 2001, Novosibirsk, 2001, P:50.
  69. Bachurin, S.O.; Tkachenko, S.E.; Baskin, I.I.; Palyulin, V.A.; Zefirov, N.S. Molecular modeling of Effective Neuroprotectors in a Series of Open-Chain Analogs of MK-801. In Proceedings of the II Russian Congress "Molecular Modeling", 24-26 April, 2001; p.15.
  70. Mukhina, T.V.; Bachurin, S.O.; Tkachenko, S.E.; Baskin, I.I.; Palyulin, V.A.; Zefirov, N.S. Neural Network Modeling of Bioactivity of MK-801 Analogs. In Proceedings of the II Russian Congress "Molecular Modeling", 24-26 April, 2001; p.86.
  71. Lermontova N., Redkozubov A., Petrova L., Serkova T. & Bachurin S. Dimebon inhibits the entry of Ca2+ into neuron and synaptosomes, which may be the action of its neuroprotective effect. Abstr. FENS Forum 2002, Paris, July 13-17, 2002. p:194.
  72. T.V. Mukhina, A.O. Lukashev, K.V. Anokhin and S.O. Bachurin. Analysing animal path trajectories in terms of individual behavioral acts. Abst. 4th International Conference on Methods and Techniques in Behavioral Research, 27-30 August 2002, Amsterdam, The Netherlands. (http://www.noldus.com/events/mb2002/).
  73. Bachurin S.O., Shevtsova E.P., Kireeva, E.G., Sablin S.O., Lermontova N.N. Mitochondria as a target for neuroprotective agents. Abst. 6th Int. Conference on Neuroprotective Agents, Sept. 15-19, 2002, Hilton Head, SC, USA, p.48.
  74. Bachurin S. Focused construction of novel neuroprotectors and cognition-enhancers for Alzheimer's disease treatment on the ground of spesific regulators of ionotropic glutamate receptors and mitochondrial transport systems. Abstr. Conf. "Basic science to medicine". Russian Academy of Sciences, Moscow, November 25-26, 2002; p:50-52. (russ)

PATENTS:

  1. Martynov I.V., Bachurin S.O., Beznosko B.K., Brel V.K., Dodonov M.V., Kartavzeva N.F., Malygin V.V., Medvedev O.S., Djuravleva L.V. 1-Difluoronitroacetyl-2-arylhydrazines posessing hypotensive activity. // Authors certificate ¹ 1432052. Inf. bull.- 1988. N.39.
  2. N.S.Zefirov, A.Z. Afanas'ev, S.V. Afanas'eva, S.O. Bachurin, S.E. Tkachenko, V.V. Grigor'ev, M.A. Yurovskaya. Derivatives of hydrogenated pyrido[4,3-b]indoles, methods of their preparation, pharmaceutical compositions and application. Russian Patent ¹ 2140417, registrated in the federal reestr of invention in Russian Federation of 27 October 1999, according to the patent application # 95117589 with priority of 17.10.1995.
  3. N.S.Zefirov, A.Z. Afanas'ev, S.V. Afanas'eva, S.O. Bachurin, E.E. Bukatina, I.V. Grigor'eva, S.E. Tkachenko, V.V. Grigor'ev, M.A. Yurovskaya, V.P. Chetverikov. An agent for the medical treatment of Alheimer's Disease. Russian Patent ¹ 2106864, registrated in the Federal register of inventions of Russian Federation of 20.03.1998, according to the patent application ¹ 95118252 with priority of 23.10.1995. (ÐÆ õèì 1999 1Î328Ï)
  4. Zefirov N.S., Afanasiev A.Z., Afanasieva C.V., Bachurin S.O., Tkachenko S.E., Grigoriev V.V., Jurovskaya M.A. Derivatives of hydrogenated pyrido[4,3-b]indoles, methods of their preparation, pharmaceutical composition and methods of treatment. Jpn.Kokai Tokyo Koho Jp. 09,216,882 [97,217,882] (Cl.C07D471/04), 19 Aug.1997. RU Appl. 95,17,585 (CA 127: P248096).
  5. Zefirov N.S., Afanas'ev A.Z., Afanas'eva S.V., Bachurin S.O., Bukatina E.E., Grigor'eva I.V., Tkachenko S.E., Grigor'ev V.V., Yurovskaya M.A., Chetverikov V.P. Agent for Treating Neurodegenerative Disorders. US Patent 6,187,785 B1; Applicant/Assignee: Selena Pharm. Inc., CA. Issued Date: February 13, 2001.
  6. Tkachenko S.E., Proshin A.N., Bachurin S.O., Petrova L.N., Zefirov N.S. - Derivatives of N,S-substituted N'-1-[(hetero)arylalkyl]-N'-[(hetero)aryl]-methylisothioureas, method of synthesis of their bases and salts, physiologically active N'-1-[(hetero)arylalkyl]-N'-[(hetero)aryl]-methylisothioureas, pharmaceutical formulation and method of treatment Appication on Russian patent on invention, ¹ 2001114922, priritet date of June 04, 2001.
  7. Mukhina T.V., Bachurin S.O. Software-Hardware complex "behavioral Vision" ("Bvision"). Sertificate for registration of software for PC. ¹2000610678. July 25, 2000.
  8. Oxenkrug; Gregory F., Bachurin; Sergei O., Afanasiev; Andrey Zakharovic, Requintina; Pura J. (Inventors). US Patent 6353015: Method of treating neurodegenerative disorders. Applicant/Assignee: St. Elizabeth's Medical Center, Boston, MA. Issued/Filed Dates: March 5, 2002 / March 23, 2001